WEHI-345
| CAS No. | 1354825-58-3 | Cat. No. | BCP23889 |
| Name | WEHI-345 | ||
| Synonyms | WEHI345; WEHI 345; | ||
| Formula | C22H23N7 | M. Wt | 401.47 |
| Description | WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. Despite only delaying NF-κB activation on NOD stimulation, WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | RIP | ||
Structure
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