O4I2
| CAS No. | 165682-93-9 | Cat. No. | BCP16032 |
| Name | O4I2 | ||
| Synonyms | O4-I2;O4I 2; | ||
| Formula | C12H11ClN2O2S | M. Wt | 282.75 |
| Description | O4I2 activates Oct3/4 in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts. O4I2 activates also other pluripotencyassociated genes such as Lin28 and Nanog in a drug-like manner. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Oct3/4 | ||
Structure
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