SU5614
| CAS No. | 1055412-47-9 | Cat. No. | BCP16040 |
| Name | SU5614 | ||
| Synonyms | SU-5614;SU 5614; | ||
| Formula | C15H13ClN2O | M. Wt | 272.73 |
| Description | SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FLT3 | ||
Structure
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