CPI-360
| CAS No. | 1802175-06-9 | Cat. No. | BCP16063 |
| Name | CPI-360 | ||
| Synonyms | CPI360;CPI 360; | ||
| Formula | C25H31N3O4 | M. Wt | 437.53 |
| Description | In KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. | ||
| Pathways | Epigenetics | ||
| Targets | Epigenetic Reader Domain | ||
Structure
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