ACY-738

Description	in vitro: ACY-738 significantly reduces the number of marbles buried, to a similar degree as a non-sedating (10 mg/kg) dose of the common anxiolytic CDP. in vivo: ACY-738 induces dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors in novel, but not familiar environments. In addition, ACY-738 given acutely at a dose of 50?mg/kg significantly decreased latency to eat in the NIH test, although this effect was not as potent as that of CDP. In the EPM, a test sensitive to anxiolytics but not antidepressants, neither ACY-738 produces behavioral changes, whereas CDP markedly increased the time in the open arms of the maze.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	HDAC

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