Ivosidenib(racemic)
| CAS No. | 1448346-63-1 | Cat. No. | BCP16173 |
| Name | Ivosidenib(racemic) | ||
| Synonyms | AG-120(racemic); AG120(racemic); AG 120(racemic); RG-120(racemic); RG 120(racemic); RG120(racemic); | ||
| Formula | C28H22ClF3N6O3 | M. Wt | 582.96 |
| Description | Ivosidenib, also known as AG-120 and RG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | IDH | ||
Structure
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