齐留通
| CAS号 | 111406-87-2 | 货号 | BCP16199 |
| 中文名 | 齐留通 | ||
| 英文名 | Zileuton | ||
| 中文别名 | |||
| 英文别名 | Zyflo;A 64077;Abbott 64077;Griluto-CR;Leutrol; | ||
| 分子式 | C11H12N2O2S | 分子量 | 236.29 |
| 生物活性 | in vitro: Zileuton inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL) (IC50 = 0.5 and 0.3 microM) respectively. It also inhibited leukotriene (LT)B4 biosynthesis by rat PMNL (IC50 = 0.4 microM), human PMNL (IC50 = 0.4 microM) and human whole blood (IC50 = 0.9 microM) [1]. Zileuton inhibited antigen-induced contractions of guinea-pig tracheal strips (GPTS) from actively sensitized animals with an IC50of 6 microM. in vivo: Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase. Neurological deficit scores, infarct volume, and neuronal damage were significantly attenuated by administration of zileuton. MCAO caused the elevation of neuronal apoptosis, which was significantly inhibited by the administration of zileuton. MCAO ca | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Lipoxygenase | ||
结构式
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