PF4447943
| CAS No. | 1082744-20-4 | Cat. No. | BCP16255 |
| Name | PF4447943 | ||
| Synonyms | PF-4447943;PF 4447943; | ||
| Formula | C20H25N7O2 | M. Wt | 395.46 |
| Description | PF-04447943 increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. PF-04447943 was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphodiesterase/PDE | ||
Structure
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