Larotrectinib
CAS No. | 1223403-58-4 | Cat. No. | BCP16262 |
Name | Larotrectinib | ||
Synonyms | ARRY-470;ARRY 470;ARRY470;LOXO-101; LOXO-101; LOXO101; | ||
Formula | C21H22F2N6O2 | M. Wt | 428.44 |
Description | Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons. | ||
Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
Targets | Trk Receptor |
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.