CEP-32496 free base
| CAS No. | 1188910-76-0 | Cat. No. | BCP16304 |
| Name | CEP-32496 free base | ||
| Synonyms | RXDX-105; RXDX 105; RXDX105; CEP32496; CEP-32496; CEP 32496; AC013773; AC 013773; AC-013773; Agerafenib; | ||
| Formula | C24H22F3N5O5 | M. Wt | 517.46 |
| Description | Agerafenib, also known as RXDX-105, CEP-32496 and AC013773, is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. CEP-32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B-raf kinase. This inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene. | ||
| Pathways | MAPK Pathway | ||
| Targets | Raf | ||
Structure
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