DASA-58
| CAS号 | 1203494-49-8 | 货号 | BCP16322 |
| 中文名 | DASA-58 | ||
| 英文名 | DASA-58 | ||
| 中文别名 | |||
| 英文别名 | DASA58;DASA 58; ML-203; ML 203; ML203; NCGC00185916; NCGC-00185916; NCGC 00185916; | ||
| 分子式 | C19H23N3O6S2 | 分子量 | 453.53 |
| 生物活性 | DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells).DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β.It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Protease/Metabolic Enzyme | ||
| 靶 点 | Pyruvate Kinase HIF | ||
结构式
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