Kevetrin hydrochloride

CAS No.	66592-89-0	Cat. No.	BCP16345
Name	Kevetrin hydrochloride
Synonyms	4-Isothioureidobutyronitrile hydrochloride;Thioureidobutyronitrile hydrochloride;Thioureido butyronitrile hydrochloride;
Formula	C5H10ClN3S	M. Wt	179.67

Description	in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
Pathways	Apoptosis Pathway
Targets	p53

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