AC-220 dihydrochloride
| CAS No. | 1132827-21-4 | Cat. No. | BCP24004 |
| Name | AC-220 dihydrochloride | ||
| Synonyms | Quizartinib 2HCl;AC010220.2HCl;AC-010220 2HCl; | ||
| Formula | C29H34Cl2N6O4S | M. Wt | 633.59 |
| Description | Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FLT3 | ||
Structure
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