Spautin-1 analogue
| CAS No. | 1262888-20-9 | Cat. No. | BCP16463 |
| Name | Spautin-1 analogue | ||
| Synonyms | Spautin 1 analogue;Spautin1 analogue;N-(4-chlorobenzyl)-6-fluoroquinazoline-4-amine; | ||
| Formula | C15H11ClFN3 | M. Wt | 287.724 |
| Description | Spautin-1 is a novel and potent autophagy inhibitor, which enhances imatinib-induced (MI) apoptosis in chronic myeloid leukemia. Autophagy has been proposed to play a role in MI resistance. Spautin-1 markedly inhibits IM-induced autophagy in CML cells by downregulating Beclin-1. Spautin-1 enhances IM-induced CML cell apoptosis by reducing the expression of the anti-apoptotic proteins Mcl-1 and Bcl-2. Spautin-1 enhances IM-induced apoptosis by inactivating PI3K/AKT and activating downstream GSK3β, leading to downregulation of Mcl-1 and Bcl-2, which represents a promising approach to improve the efficacy of IM in the treatment of patients with CML. | ||
| Pathways | Others Pathway | ||
| Targets | Autophagy | ||
Structure
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