Ro 0281675
| CAS号 | 300353-13-3 | 货号 | BCP16457 |
| 中文名 | Ro 0281675 | ||
| 英文名 | Ro 0281675 | ||
| 中文别名 | |||
| 英文别名 | Ro-0281675;Ro0281675; Ro 28-1675; | ||
| 分子式 | C18H22N2O3S2 | 分子量 | 378.51 |
| 生物活性 | IC50 value: 0.24± 0.0019 uM (SC1.5) Target: Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with a SC1.5 of 0.24 uM, while the S isomer did not activated GK up to 10 uM. Oral administration of Ro 28-1675 (50 mg/Kg) to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle treated animals . Comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Following a single oral dose, Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT, was well tolerated, and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg). | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Glucokinase | ||
结构式
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