地美溴铵
| CAS号 | 56-94-0 | 货号 | BCP24065 |
| 中文名 | 地美溴铵 | ||
| 英文名 | Demecarium bromide | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C32H52Br2N4O4 | 分子量 | 716.59 |
| 生物活性 | Demecarium is a parasympathomimetic that acts as an acetylcholinesterase inhibitor. It is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals. a cholinesterase inhibitor with sustained activity. It acts mainly on true (erythrocyte) cholinesterase. Application of HUMORSOL (demecarium) to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug. HUMORSOL (demecarium) indirectly produces some of the muscarinic and nicotinic effects of acetylcholine as quantities of the latter accumulate. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | AChE | ||
结构式
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