Vilaprisan
| CAS No. | 1262108-14-4 | Cat. No. | BCP24069 |
| Name | Vilaprisan | ||
| Synonyms | BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670; | ||
| Formula | C27H29F5O4S | M. Wt | 544.58 |
| Description | Vilaprisan, also known as BAY1002670 or BAY10-02670, is a potent and selective oral progesterone receptor modulator that holds the promises of long-term treatment of patients with symptomatic uterine fibroids. BAY1002670 in subnanomolar concentrations exhibits a highly selective binding profile and antagonistic activity for the PR. These properties are also reflected in its action in two progesterone-dependent animal models that assess the termination of pregnancy and endometrial transformation. In a human fibroid xenograft model BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005). | ||
| Pathways | Hormone Pathay | ||
| Targets | Progesterone Receptor | ||
Structure
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