SM-164
| CAS No. | 957135-43-2 | Cat. No. | BCP16589 |
| Name | SM-164 | ||
| Synonyms | SM 164;SM164; | ||
| Formula | C62H84N14O6 | M. Wt | 1121.42 |
| Description | SM-164 is developed as an anticancer agent. It plays its antitumor roles through inducing degradation of cellular inhibitor of apoptosis protein (cIAP)-1/2, antagonizing X-linked inhibitor of apoptosis protein (XIAP) and inducing TNFα–dependent apoptosis in tumor cells. SM-164 is a bivalent mimetic containing two SM-122 analogues. It binds to cIAP-1 protein containing bothBIR2 and BIR3 domains, cIAP-2 BIR3 protein and XIAP protein containing both BIR2 and BIR3 domains with Ki values of 0.31 nM, 1.1 nM and 0.56 nM, respectively. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | IAP | ||
Structure
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