AMG-337
| CAS No. | 1173699-31-4 | Cat. No. | BCP16602 |
| Name | AMG-337 | ||
| Synonyms | AMG 337;AMG337; | ||
| Formula | C23H22FN7O3 | M. Wt | 463.46 |
| Description | in vitro: AMG-337 demonstrates exquisite selectivity for MET when profiled against a diverse panel of over 400 protein and lipid kinases in a competitive binding assay. In cellular assays, AMG 337 inhibits HGF-dependent MET phosphorylation with an IC50 of < 10 nM. AMG 337 is a selective inhibitor of Met, which inhibits multiple mechanisms of Met activation. in vivo: AMG-337 demonstrates robust activity in MET-dependent cancer models. Oral administration of AMG 337 results in robust dose-dependent anti-tumor efficacy in MET amplified gastric cancer xenograft models, with inhibition of tumor growth consistent with the pharmacodynamic modulation of MET signaling. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | c Met | ||
Structure
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