NSC59984
| CAS No. | 803647-40-7 | Cat. No. | BCP16647 |
| Name | NSC59984 | ||
| Synonyms | NSC-59984;NSC 59984; | ||
| Formula | C12H15N3O4 | M. Wt | 265.27 |
| Description | NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells. It is reported to induce cell death in colon cancer cells (EC50 = 8.38 μM in p53-null HCT116 cells) without evident toxicity toward normal cells. NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | p53 | ||
Structure
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