PS-1145
| CAS No. | 431898-65-6 | Cat. No. | BCP24095 |
| Name | PS-1145 | ||
| Synonyms | PS 1145; PS1145; | ||
| Formula | C17H11ClN4O | M. Wt | 322.75 |
| Description | PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. PS1145 induced caspase 3/7-dependent apoptosis in PC cells and significantly sensitized PC cells to apoptosis induced by tumor necrosis factor alpha. PS1145 inhibited PC cell proliferation. PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats. PS1145 can overcome imatinib resistance. | ||
| Pathways | NFκB | ||
| Targets | IκB/IKK | ||
Structure
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