AF-353 hydrochloride
| CAS No. | 927887-18-1 | Cat. No. | BCP24140 |
| Name | AF-353 hydrochloride | ||
| Synonyms | Ro 4 hydrochloride;AF353 HCl; | ||
| Formula | C14H18ClIN4O2 | M. Wt | 436.68 |
| Description | AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats. | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | P2 Receptor | ||
Structure
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