CYM5442
| CAS No. | 1094042-01-9 | Cat. No. | BCP16797 |
| Name | CYM5442 | ||
| Synonyms | CYM-5442;CYM 5442; | ||
| Formula | C23H27N3O4.HCl | M. Wt | 446 |
| Description | CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. CYM-5442 significantly inhibited but did not prevent aGVHD. CYM-5442 treatment downregulated CCL2 and CCL7 expression in endothelial cells, therefore reducing the migration of monocytes, from which tissue macrophages originate. CYM-5442 may be a potential therapeutic regimen for aGVHD. | ||
| Pathways | GPCR/G Protein | ||
| Targets | S1P Receptor | ||
Structure
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