BPR1J-097
| CAS No. | 1327167-19-0 | Cat. No. | BCP16866 |
| Name | BPR1J-097 | ||
| Synonyms | BPR1J097; BPR1J-097; BPR1J 097; BPR1-J097; BPR1 J097; BPR1J097; | ||
| Formula | C27H28N6O3S | M. Wt | 516.61 |
| Description | BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities. BPR1J-097 may be useful in AML treatments.IC50 of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC(50)s) were 21?±7 and 46?±14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FLT3 | ||
Structure
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