SW-044248
| CAS No. | 522650-83-5 | Cat. No. | BCP16844 |
| Name | SW-044248 | ||
| Synonyms | SW 044248;SW044248; | ||
| Formula | C22H23N5O2S | M. Wt | 421.52 |
| Description | SW044248 inhibits Top1 and not Top2 and appeared to do so by a mechanism different from camptothecin (CPT). SW044248 is a selectively cytotoxic chemical with activity against certain NSCLC cell lines. SW044248 rapidly inhibits transcription, translation, and DNA synthesis in sensitive cells but not insensitive cells. SW044248 kills approximately 15% of a panel of 74 NSCLC cell lines and is nontoxic to immortalized human bronchial cell lines. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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