Nastorazepide
| CAS号 | 209219-38-5 | 货号 | BCP16894 |
| 中文名 | Nastorazepide | ||
| 英文名 | Nastorazepide | ||
| 中文别名 | |||
| 英文别名 | Z-360;Z 360;Z360; | ||
| 分子式 | C29H36N4O5 | 分子量 | 520.62 |
| 生物活性 | in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Cholecystokinin Receptor | ||
结构式
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