LGH447 Hydrochloride
| CAS No. | 1210416-52-6 | Cat. No. | BCP24206 |
| Name | LGH447 Hydrochloride | ||
| Synonyms | LGH447; LGH-447; LGH 447; PIM-447 HCl; PIM-447; PIM 447; PIM447; | ||
| Formula | C24H24ClF3N4O | M. Wt | 476.93 |
| Description | LGH447 Hydrochloride is Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects. LGH447 Hydrochloride is also know as PIM447, PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). | ||
| Pathways | Jak/Stat Pathway | ||
| Targets | Pim | ||
Structure
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