C-DIM12
| CAS No. | 178946-89-9 | Cat. No. | BCP17151 |
| Name | C-DIM12 | ||
| Synonyms | CDIM12;C DIM12; | ||
| Formula | C23H17ClN2 | M. Wt | 356.85 |
| Description | C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | Dopamine Receptor | ||
Structure
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