PRT4165
| CAS No. | 31083-55-3 | Cat. No. | BCP17178 |
| Name | PRT4165 | ||
| Synonyms | NSC 600157;PRT 4165;PRT-4165;NSC-600157;NSC600157; | ||
| Formula | C15H9NO2 | M. Wt | 235.24 |
| Description | PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | E1 E2 E3 Enzyme | ||
Structure
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