ML098
| CAS No. | 878978-76-8 | Cat. No. | BCP17208 |
| Name | ML098 | ||
| Synonyms | ML-098;ML 098; | ||
| Formula | C19H19NO3 | M. Wt | 309.36 |
| Description | They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). It has been shown to function by increasing the affinity of the GTPase for guanine nucleotides. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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