Brevianamide F

CAS No.	38136-70-8	Cat. No.	BCP24252
Name	Brevianamide F
Synonyms	Cyclo-L-Trp-L-Pro;cyclo-L-tryptophanyl-L-proline;cyclo-(Trp-Pro)；Cyclo(L-Pro-L-Trp);
Formula	C16H17N3O2	M. Wt	283.33

Description	Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. It is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp. It has been isolated from the bacterium Streptomyces sp. strain TN58 and shown to possess activity against two Gram-positive bacteria, S.aureus and Micrococcus luteus, and has also been isolated from Bacillus cereus associated with the entomopathogenic nematode, Rhabditis (Oscheius) sp. and shown to have antifungal activity against T. rubrum, C. neoformans and C. albicans, better than amphotericin B
Pathways	Ion Channel/Membrane Transporter
Targets	BCRP

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