SCH 51344
| CAS No. | 171927-40-5 | Cat. No. | BCP17385 |
| Name | SCH 51344 | ||
| Synonyms | SCH-51344;SCH51344; | ||
| Formula | C16H20N4O3 | M. Wt | 316.36 |
| Description | SCH-51344 is an inhibitor of RAS/RAC-mediated cell morphology pathway. RAS interacts with multiple targets in the cell and controls at least two signaling pathways, one regulating extracellular signal-regulated kinase (ERK) activation and the other controlling membrane ruffling formation. SCH 51344 specifically blocks membrane ruffling induced by activated forms of H-RAS, K-RAS, N-RAS, and RAC. SCH 51344 was effective in inhibiting the anchorage-independent growth of Rat-2 fibroblast cells transformed by the three forms of oncogenic RAS and RAC V12. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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