LY 294002 hydrochloride

CAS No.	934389-88-5	Cat. No.	BCP17476
Name	LY 294002 hydrochloride
Synonyms	LY 294002 HCl;LY-294002 hydrochloride;LY294002 hydrochloride;
Formula	C19H17NO3.HCl	M. Wt	343.8

Description	LY294002 inactivates Akt/PKB, consequently inhibiting cell proliferation and inducing apoptosis. LY294002 demonstrates a remarkable growth-inhibitory and apoptosis-inducing effect in these colon cancer cell lines, with decreased expression of phosphorylated Akt (Ser473). LY294002 induces marked nuclear pyknosis and diminished cytoplasmic volume in the tumor cells. Thus, LY294002 markedly inhibits ovarian cancer cell proliferation in vitro. LY294002 induces specific G1 arrest in cell growth, leading to almost complete inhibition of melanoma cell proliferation and partial inhibition of MG-63 (osteosarcoma cell line) proliferation. The effect of LY294002 on cell cycle progression may provide insights into a possible link between the PI3K activation pathway and cancer cell cycle regulation.
Pathways	PI3K/Akt/mTOR
Targets	PI3K

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