Pyridostatin hydrochloride
| CAS No. | 1416230-43-7 | Cat. No. | BCP17557 |
| Name | Pyridostatin hydrochloride | ||
| Synonyms | RR-82 hydrochloride;RR 82 hydrochloride;RR82 hydrochloride; | ||
| Formula | C31H33ClN8O5 | M. Wt | 633.1 |
| Description | Pyridostatin stabilizes G-quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets gene bodies containing clusters of sequences with a propensity for G-quadruplex formation. As a result, pyridostatin modulated the expression of these genes, including the proto-oncogene SRC. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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