Pifithrin-β hydrobromide
| CAS No. | 511296-88-1 | Cat. No. | BCP17578 |
| Name | Pifithrin-β hydrobromide | ||
| Synonyms | Cyclic Pifithrin-α hydrobromide; Cyclic PFT-α hydrobromide; PFT-β hydrobromide; QB 102; QB-102; QB102; | ||
| Formula | C16H16N2S.HBr | M. Wt | 349.29 |
| Description | Pifithrin-β is a cyclic analog of pifithrin-α, a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | p53 | ||
Structure
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