LY2811376 2HCl salt
| CAS号 | 1194043-85-0 | 货号 | BCP24326 |
| 中文名 | LY2811376 2HCl salt | ||
| 英文名 | LY2811376 2HCl salt | ||
| 中文别名 | |||
| 英文别名 | LY-2811376 2HCl salt;LY 2811376 2HCl salt; | ||
| 分子式 | C15H16Cl2F2N4S | 分子量 | 393.28 |
| 生物活性 | LY2811376 is a potent and selective BACE1 inhibitor (IC50 = 239 nM for the synthetic peptide) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over the aspartyl proteases cathepsin D, pepsin, and renin.3 LY2811376 treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage. The β-secretase enzyme, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), cleaves amyloid precursor protein (APP) in the first step in β-amyloid (Aβ) peptide production. Thus, BACE1 is a key target for candidate disease-modifying treatment of Alzheimer's disease. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | Beta secretase | ||
结构式
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