Defactinib hydrochloride
| CAS No. | 1073160-26-5 | Cat. No. | BCP17737 |
| Name | Defactinib hydrochloride | ||
| Synonyms | PF-04554878 hydrochloride;PF04554878 hydrochloride;PF 04554878 hydrochloride;VS6063 hydrochloride;VS 6063 hydrochloride;VS6063 hydrochloride; | ||
| Formula | C20H22ClF3N8O3S | M. Wt | 546.95 |
| Description | VS-6063 inhibited FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. The combination of VS-6063 and paclitaxel markedly decreased proliferation and increased apoptosis, which resulted in 92.7% to 97.9% reductions in tumor weight. RPPA data showed that VS-6063 reduced levels of AKT and YB-1 in taxane-resistant cell lines. FAK inhibition enhanced chemosensitivity in taxane-resistant cells by decreasing YB-1 phosphorylation and subsequently CD44 in an AKT-dependent manner. | ||
| Related Products | 1073154-85-4（Defactinib） 1345713-71-4（Defactinib） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase PI3K/Akt/mTOR | ||
| Targets | PI3K FAK | ||
Structure
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