SLV-308 hydrochloride

CAS No.	269718-83-4	Cat. No.	BCP17730
Name	SLV-308 hydrochloride
Synonyms	Pardoprunox hydrochloride;DU-126891 hydrochloride;DU126891 hydrochloride;DU 126891 hydrochloride;SLV-308 hydrochloride;SLV 308 hydrochloride;SLV308 hyd;
Formula	C12H16ClN3O2	M. Wt	269.73

Description	Pardoprunox, also known as SLV-308; DU-126891; SME-308, is dopamine D2/5-HT1A receptor agonist potentially for the treatment of Parkinson's disease. It was also being investigated for the treatment of depression and anxiety but these indications appear to have been abandoned. Pardoprunox acts as a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%). It also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	5 HT Receptor/Serotonin Receptor Adrenergic Receptor Dopamine Receptor

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