RO 9021
| CAS No. | 1446790-62-0 | Cat. No. | BCP17963 |
| Name | RO 9021 | ||
| Synonyms | RO-9021;RO9021; | ||
| Formula | C18H25N7O | M. Wt | 355.44 |
| Description | RO9021 is an oral, ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK). RO-9021 potently inhibited SYK kinase activity with an average IC50 of 5.6 nM. RO-9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90), indicating that SYK is the only kinase with 99% competition with RO-9021 (1 uM) in a total of 392 tested kinases. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Syk | ||
Structure
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