MGL-3196
| CAS号 | 920509-32-6 | 货号 | BCP24624 |
| 中文名 | MGL-3196 | ||
| 英文名 | MGL-3196 | ||
| 中文别名 | |||
| 英文别名 | MGL 3196; MGL3196; VIA 3196; VIA3196; VIA-3196;Resmetirom; | ||
| 分子式 | C17H12Cl2N6O4 | 分子量 | 435.22 |
| 生物活性 | MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). MGL-3196 shows outstanding safety in a rat heart model and is efficacious in a preclinical model at doses that showed no impact on the central thyroid axis. | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Thyroid Hormone Receptor | ||
结构式
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