RS-1
| CAS No. | 312756-74-4 | Cat. No. | BCP18095 |
| Name | RS-1 | ||
| Synonyms | RS1;RS 1;RAD51-Stimulatory Compound-1; | ||
| Formula | C20H16Br2N2O3S | M. Wt | 524.23 |
| Description | RS-1 is an activator of DNA repair protein RAD51 (Kd = 48-107 for human RAD51 with different cofactors present).It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51.RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing homology directed repair 3- to 6-fold.It is used to increase CRISPR-mediated knock-in efficiencies in vitro and in vivo. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | RAD51 | ||
Structure
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