CPI-637
| CAS No. | 1884712-47-3 | Cat. No. | BCP18221 |
| Name | CPI-637 | ||
| Synonyms | CPI637;CPI 637; | ||
| Formula | C22H22N6O | M. Wt | 386.45 |
| Description | CPI-637 is a potent and selective CBP/ EP300 bromodomain inhibitor. The biochemical potency of CPI-637 translated well into cells (CBP BRET EC50 = 0.3 μM). CPI-637 demonstrated a >700-fold selectivity over the BET family of bromodomains (BRD4 IC50 = 11.0 ± 0.6 μM). CPI-637 inhibits MYC expression in AMO-1 cells (EC50 = 0.60 μM). CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Acetyltransferase Epigenetic Reader Domain | ||
Structure
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