Casopitant
| CAS No. | 414910-27-3 | Cat. No. | BCP18249 |
| Name | Casopitant | ||
| Synonyms | GW679769; GW 679769; GW-679769; | ||
| Formula | C30H35F7N4O2 | M. Wt | 616.62 |
| Description | Casopitant is a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | NK Receptor | ||
Structure
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