NS-398
| CAS No. | 123653-11-2 | Cat. No. | BCP18285 |
| Name | NS-398 | ||
| Synonyms | NS398;NS 398; | ||
| Formula | C13H18N2O5S | M. Wt | 314.36 |
| Description | in vitro: NS-398 suppresses DOX-Induced Cytotoxicity and p53 Accumulation in U2OS and MCF-7 Cell Lines. NS-398 pre-treatment significantly reduces DOX-induced cytotoxicity in both cell lines. NS-398 reduces doxorubicin (DOX)-induced p53 accumulation and cytotoxicity. in vivo: NS-398 attenuates subretinal fibrosis, in an experimental model of subretinal scarring observed in neovascular AMD, by down-regulation of TGF-β2 in the retinal pigment epithelium-choroid complex. NS-398 can attenuate CNV and subretinal fibrosis lesions by suppressing macrophage infiltration and downregulating VEGF and TGF-β2, respectively. | ||
| Pathways | Neuro Signaling Pathway | ||
| Targets | COX | ||
Structure
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