NSC177223
| CAS No. | 36707-00-3 | Cat. No. | BCP24669 |
| Name | NSC177223 | ||
| Synonyms | NSC-177223;NSC 177223;API1; API-1; API 1; | ||
| Formula | C13H15N5O6 | M. Wt | 337.29 |
| Description | NSC177233 is a potent Akt inhibitor, which induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1. API-1 treatment decreased the half-life of Mcl-1, whereas inhibition of the proteasome with MG132 rescued Mcl-1 reduction induced by API-1. API-1 decreased Mcl-1 levels accompanied with a rapid increase in Mcl-1 phosphorylation (S159/T163). Moreover, inhibition of GSK3 inhibited Mcl-1 phosphorylation and reduction induced by API-1 and antagonized the effect of API-1 on induction of apoptosis. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | AKT | ||
Structure
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