GSK-2256098
| CAS号 | 1224887-10-8 | 货号 | BCP18311 |
| 中文名 | GSK-2256098 | ||
| 英文名 | GSK-2256098 | ||
| 中文别名 | |||
| 英文别名 | GSK 2256098;GSK2256098; GTPL7939; GTPL-7939; GTP L7939; | ||
| 分子式 | C20H23ClN6O2 | 分子量 | 414.89 |
| 生物活性 | FAK inhibitor GSK2256098 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thereby inhibiting tumor cell migration, proliferation and survival, and tumor angiogenesis. The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FAK | ||
结构式
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