EPI 001
| CAS No. | 227947-06-0 | Cat. No. | BCP18361 |
| Name | EPI 001 | ||
| Synonyms | EPI-001;EPI001;BADGE-HCl-H2O;Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether; | ||
| Formula | C21H27ClO5 | M. Wt | 394.89 |
| Description | EPI-001 blocks transactivation of the AR NTD, interacts with the AF-1 region, inhibits protein-protein interactions with AR, and reduces AR interaction with androgen-response elements on target genes. In LNCaP cells, EPI-001 inhibits both androgen-dependent and androgen-independent (OCM-induced) cell proliferation.In LNCaP cells, EPI-001 also acts as a PPAR-gamma modulator to result in inhibition of androgen receptor expression and activity, which inhibits prostate cancer growth. | ||
| Pathways | Hormone Pathay | ||
| Targets | Androgen Receptor | ||
Structure
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