ITSA-1

  • Chemical Properties
CAS No. 200626-61-5 Cat. No. BCP18420
Name ITSA-1
Synonyms ITSA1;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole;
Formula C13H7Cl2N3O M. Wt 292.12
  • Biological Activity
Description ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.
Pathways Cell Cycle/DNA Damage Epigenetics 
Targets HDAC 

Structure

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