Umbralisib tosylate
| CAS号 | 1532533-72-4 | 货号 | BCP24684 |
| 中文名 | Umbralisib tosylate | ||
| 英文名 | Umbralisib tosylate | ||
| 中文别名 | |||
| 英文别名 | TGR-1202 tosylate; RP5264 tosylate;TGR-1202 (4-methylbenzenesulfonate); | ||
| 分子式 | C38H32F3N5O6S | 分子量 | 743.75 |
| 生物活性 | Umbralisib Tosylate is the tosylate form of umbralisib, an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. umbralisib inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | PI3K | ||
结构式
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