Endoxifen hydrochloride

CAS No.	1197194-41-4	Cat. No.	BCP24689
Name	Endoxifen hydrochloride
Synonyms	Endoxifen HCl;Z-Endoxifen hydrochloride;
Formula	C25H28ClNO2	M. Wt	409.95

Description	Endoxifen Hydrochloride is the hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of tamoxifen, competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA and thus reducing DNA synthesis. Unlike tamoxifen, however, which relies on CYP2D6 activity for its conversion to the active metabolite endoxifen, the direct administration of endoxifen bypasses the CYP2D6 route. As CYP2D6 activity can vary widely among individuals due to genetic CYP2D6 polymorphisms, endoxifen is therefore theoretically more potent and more uniform in its bioavailability across patient populations.
Pathways	Hormone Pathay
Targets	Estrogen Receptor

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